	   SnapGene      ’GTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCgccaccatgcggcggggctggaagatggctctgtctggggggttgcggtgctgccgccgggtactgtcctgggtgccagtgctcgttattgtcctcgtcgttctctggtcctactatgcctacgtctttgaactctgcctggtgactgttttgagtccagcggaaaaagttatctacctcatactctatcatgccatttttgtgttctttgcatggacctactggaagtctatcttcacactcccacagcagccaaaccagaagttccacttgtcctatacagacaaggagcgctataaaaatgaagagagacctgaggtccagaagcagatgcttgtggacatggccaagaagttaccagtgtacacaagaaccgggagtggagctgtacggttctgtgaccggtgccatctaatcaagccagaccgctgccatcactgttctgtctgtgccatgtgtgttttaaaaatggaccatcactgcccatgggttaataactgcattggattttccaactacaaattcttccttcagttcttagcttattccgttctctactgcctgtacattgctacaacagtcttcagctacttcatcaaatactggagaggggaattgcccagtgttcgctctaagttccatgtcctctttctcctctttgtggcctgcatgttttttgtcagccttgtgattctctttggttaccattgttggcttgtcagcagaaacaaaactaccttagaggccttctgcacaccagtattcacaagtggaccagagaaaaatgggttcaatcttggcttcatcaagaatattcagcaggtgtttggcgataataagaagttctggttaatacccattgggtccagccctggtgatggacactccttccctatgaggtctatgaatgagtcacagaacccgctgctggcaaatgaggaaccctgggaagacaatgaggatgatagtcgagattatccagaaggctcatcatcacttgctgtggagtcggaaacgCTCGAGTACCCATACGACGTACCTGATTATGCAACTTATCCTTATGATGTACCTGATTATGCTAGCTATCCTTATGATGTCCCAGACTACGCATAGTGAGGGCCCGATATCTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAGCTGACGTCCTTTCCATGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGAAACGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCAGATCTGCGCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGCATCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGGGGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTCGACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGG  =%                  $                       $      /                   %                                    $                                 +               #         "   %            0      %   1      '       *            #                                                        ;         "                        !                         !               %   "                                                         '   #   *            #   #                   )   -                                    #               #      !   #                "      2   (   !      )   .                  !   !      '      &         "   $   #   !         "                                  +   2            (                         #               +      $   /         !             -   %      #   !   %            3   ,      &      (      '         +      +         Y áÈßàá„­}	~	ï	#
v
›
¤
¥
I"sÞŸ½*¬`œ® á xâ b2m<®ç	#¼úÿ‚ ý+­ª…Uô_,à Z ÷ âõ¢ÍÓ	Ú	ð	W
¦
Ï
W‰v!q¾at¯  ÈNÉ…’f	ý	$
d
w
œ
Jœ<tÐß¸n@òYµ�4 t û cÚ38§Õ€	–	Å“Ÿ½%­,Vá<$ ´Î\šen­_¯w	’	¢	¦	íe|Äû±Gu§þ¸Ýc«àq±õŽ-=  Îãž³z3sÜZ	$Òäê!­ÆZŽ¡®�i@†¡`­‡Û â y!‘‘¾*=è	Û¬ Ïz†ƒE´  ø ¬_±éGNð$ö¤Ô	X
Ð
Õ
Šw¿"˜Dr¿4Úƒ™: Œ MR’öO§
Ò~“Í#=bx¿ìM ´ÕãB£vÎ
Âñ	Ø
X�°3|jØ4›b—Öu° [ f%ø=Û	ö	¸iiàb�éÆ¤ö?$  ÉOVÅ÷ñ\x
¾
Ì
uÑ_*w®±^1Aw�ö7V³€r>Tž5 ]‡º\é“·	
{
Km”Ü=²Uû2Üh/ œ {ÊÕƒÙ“¢†‹Ä+	ƒ	þ	e
�
0ˆÐK–¨*2MfºÃQbuàûm’¹oŠqó§Z�Rm    “ TQ¢Ý	 	3	g	%
^

�+hn¢ÇNiÍØêœf¶Á dö ;cxÓ�	fl‘” è(°/2vW= íïÄ…—	
Þ&@I-“/½â u ü S4H¨·ÖU	Æ®É2ŒçßýuEF t˜Û9>~¾�¡Ö¨X¢ÍzÅrº
ƒQ% Ï›¿êþo�°“	£	[
˜à‰õü²Ó¥¨d¬”±ÐIÂ²Áö·g� ]�Æ®Cx	‹	}ÅB�H$f~ÿ¹:á8v�¡>žÄ µäDÆ	Xf ;´v¦1.F“„ <-Pf`§	îü¤î½Þÿrw  ¯Ò'{áÿ�åVU®Ç-�É % Ïú~t
©œ¯O‘GPwaˆ 7 ä´l‡Ìê4GÝ^„%Cø[áKQj-‡•– Ÿ[	Ž
ÓØë"pÁÊ’¢öALT¢®l~¬®¿ãÜäì ¹ Å î AJûEÃ	¶éR	´	­¿­ÍéÐ5„%gÒØ 1 Õ+r%€™™	Â	àF‡ABµî8v > ã zÚ"JK>ÜO8c[FG7ú   « p’ñJb’¿	
ç
u‹�…#{½)-L€�Ar$ ù Ì`¯²6O¼¥qÛïô¢Ó
Ö
šÙczÂ#ÁEgu5±—šoÄ8 ­HHj%AY
å
‹�!š|ËÃ #Y­„#‚„)ñ÷ ¥ÐÕ	Ñ
jlxÀ_sz²Û÷B;È657 ê	O{ùd™ãÉÀ	où„m‹‚×ÉK S¹
—ŒÊÝ}íDH M � Õ N2a´”ã$>cáÿºÌ È þ %•²PŠž·¨
›ãÄFÓ2B;Îy¹À×N8—$  3j‹¾[“÷%>î¹Æä§ . ä€^ÃØâ�§Ò×	Âì�kâðé0î #ˆ°¾GºC9   C ~ c¤wÙ
4rÙ„œ×€òw˜Ê×v  µÖ‚N†Zóß	4
±ï{Ås5ùYÅI + c w Ì †ÂCrÐà+6Ïã	ò	S
)Y‘Îã4a}Ôó°m{ÖäŽ%c•Å± /‚ªªW	Ü	

s
¾Iújá?FÕ÷@ \ ¼ ñ D›þaˆJå.:n´üj†ï*j.Ž=³õ'W ígÛ6žwþ>É?	¹>-cêã| ¨ü&UËù=¹ìù÷	È�É	”"˜4Ç¥# ²ÓPÃÆçZ]å		1	í	y
¼
Ê
Í
¸ø]`x¯�(2u|‘�•<…  øVŽŸ+²"3x8t}s?Ÿ6O  , | ÊW€ò=	2
ã
Ò�_à9î÷W¯Uþ"  Ýã­	“
²
¿
È
Þ
ø
 nv¶Ûåé›å&Bcq´Æ3¼j¶M% ˆ»q³Œíj
|
‹
•
à
‘•ÙÝcp©³ÝæÌµVYo'*5¾ÅÝt H]Òê¸	Ÿ¸ç ¯XåÇÒü#rŸÌ�$Si ^�®VÁ
L¤¨ìðôf˜Øëë«3åëj} ªû”Ï	
n
>£û	àÙ¸0  � Ëì;fVY¢yÆy|Œ³Å%	ÿ	˜
@LNgÄàRcn¢º‹ªp`róÇïôÍ
o·C ¡|ßõðôl‘ô„	¯	ë
€+3»	v“TÏ†¨ù,^%  Ž×„Ú|—£E1f—©Àl4RªÁËpÏZòL‰¶û[S1nŠ1 všÖ/”³a2‡È,	f
ž
?‰Ñ¶Qå7áüÛ‹çDTe…(gsÁèÈðjˆ�B]œJ„* ïòi(	h	-ioY\=µë8OjØZ‡¤ë†®·ñÂ!' ! Ú .»{¶Q^i}$WÕ&
m
…
ô
$žÈç÷A ÎÙO\Óª
&úlË   ˜ Y0CêRe£„lpÌ!	4	E	k	s	,rx£0ðú]¹Âœ�3Ø* j ” ¤ ² 7Ue=œ$Þu	K	.
_
€
´
ú
¤¸#/9Dx›}8·î
gP à ƒü	c
£
VˆurþÝ«„X´+3s­ ÙdyÔ•	¥	’ãé« Å…·ÜDh³? ¬ e÷ï<¾i3Ìßw>#  U¡’è‚	]
~
‡“ÏÛgm•¡§)±ú0�Ì×éU1qgl sìîŸÃeÝ'Õ§W.1q‹æü ¾ý,ŽÅãO�Å	—ßˆA¥¼°7HÀ¶0v�ƒ $ Ñ†F�
JN,K”­F•¾ã ÔðaqQ	˜	Á	
¬ßEŠA€ "¬"5(»c™ØŽ±Ê–nlÃÇ5�ÈJ L Ô ý 2iŠ½±¸šâ‹E¸Öàþ¹#G  B b v bÁÏ5×R
q3¯Õ�ÖèÄñ/v½FÄ šì§T�ýI�©V	Ç€³Èûù-3â& ÒYÜ	»
Ç
â
÷
ÿ
mµ÷�žŒè2š{®s»”ý„  p² ‹ìŠ
�£·Øëÿ¢×äêªÆÑXn&)žßsêiR u�™:Öó1²—
>?µ¿ß©ÎSYoÎ„fîïø\›] i µ]dl
´ê£¸[Ò©­ Ø‘”	¤	\
ý hŽËÖè²>ƒŸ³p«*2fk Ðë+â pEÀ	Ü ‰Ô¦»M@åGJ‚ !1ëaœÀ4ºQ
™ÇáŠD°,•ÃÕÂ¸¼%€Ç oŒÿ\±Æ
=¢ê´öŒ³1ã ©·e­íÑ%÷“h\ `D¿	~¡Æé³Cgâÿ¯¶�ºÊÕçLä=žÔ’)Æ; *^_äå‹Œ”ÇÈ:½	¾	Ê	{|}789KL±²IÉÔåæâã9:;<wœ�¼½��‘~�¢&'(Ÿ ÅU � P+Jæ�ÂÉ_;»D:MJ%Þòû ·¾Ê?¡©V 	†¹�•¯y	Œ	Ë	é	~è‘& ;þxã¤‘£¥" � Â ô GQÅ,KçŽÊE`u�;g¡ZKµ&Õ/Æ¾¿øt@” I ¿ Ý §åýœ	º	Ç	)
Õ<ßçü–¡2Zd/G^¢ª S ¶Ã <œNY]¯÷Só€‘Ü¸êéWy O XÓ(¼	EIwc§!ËÏÿ… ¨ × °ìz	Ì	ê	p
S#²si’ 4ú‘�	ïòHýB’›¾eÿ¦c … 
7‡=ª¼–ÔXa‡	é)¥ïÀ'Ò&¡yäJÎx¤ß º.Qg,¨	ùº<ß< 8¥!Î! r ‘ õ RvªÆLÓ�� Ë( ÂŽIO¯(BL¶ÖgPÔÚô  Ã Hnè9BFav|ßýÑ²	<æö6¢È'd�Ç‘ÀÝu|�  Ê -€;Xâ \oh0<Á{†ÊA• ,c°Á.yÐî‚��¦åîaWV[	.¨¿ùø: J g Ò Þ Ðˆ
ªÖŠèm-3q« ƒ À mâ¨ûþ¹»	È	ç	Óàý­°JH¢çb0£ & n p *kæÆ=�ÙÛ_� ( oÐ¿u�	
*
hDž—P’Qx[eHN‰! 4 ; ¶ ë >øB°ò!}H”!T 
0ùŸÉ�Ý=ë)‹dyz 8 F T _ `—¤ˆÍë5Ã
…Z°øÙk.–¹ça  å~µ=©_&DOT]ÌLô»ˆ —l�™¼X ·ÄÛm´èR�Þ	^=ƒ.�\âR’Xê* žfF¡ìJ¾•š`Õí÷x"*L5­Ý% P 'ÂvYl–ß˜›)ŒÙLÂÚ?‚Dí,9d�¨™Ì ›mÍˆp" �f¢TÔ \	�
ÿªòÔ#-Ë£4ÐÂBU£Ðb¯äíå&†  ‹Ù÷½		ª
NÈHq“‡Ÿ÷M¯)ÔÞýÀí  W Š Kß]@Z{	�	µ	Ñ	k®ÎÐ™¥^S];Ù © ÁS	®ËÑG ýEtNj º Æ ï B“ü4Äí·ê÷q
'•ÀÌê¥~“Ó * Ø 5F±jw
Í	ë	,
°
Ü
Tj6…$³&Å1h†@ °ÒûM�Ã	áC£Bf‰¶ï/ 5Ö)Àø’¸s&8šš	ðIþ@GÜðù�™ §adw 2 � l�Àð“ˆœ×¿zo‹º ¨'¬,Ž	î
ó—C«9 ùK—o™«çLý–ˆ	ê9¦òðdëXR_âòà ? ¤+½—	YPG'¢­K † ä {ƒ#ˆÇžÕ?ð
€ÁHåÏyô Û8>qª.b
Ýõ*©(Ó\‰z8Ð¥ÓJPû ¡ •/KcŸ	
è
Œ|¾*WFà�zŒBg´s §¾»“z®À'»†‰.Rõ_¦"ú qj“òšÈæ-*Ø	p�2y=M”Ú©Î ¬ óRh»©	

E
J
vú$–»=�9‚ÏÛ ö wÇMaÞ ¡Ìl‘e	Ù	"
š
›! ;p·m¼?ñ' s ú Í³Í�™7�²½)¦2r~Ûv	ÄÚìd{Ãž$°ÎFY�¬bp�;# «‘°$Fu	#NÁõ£Ô
×
�2C×ha˜¾ëŒèÅ9LÕõ* ’ › S\†¹zÔP‚Øö[¡ÜðÃ
JÂÆP)Mhv‘­]õ6²T›eQÀÛ Rõ:GbwÒ=}�çÈÌÄ1’Þ.¼	‚E ;éCBŠ	Z
ûŸ£ô¤e}“ÏÁEf’€ 6 ®k&}ËàéþƒŒ¨B×÷UToÉ›‘õSv}â# 0 = Ÿ ¸ Ä í @IoÙúDIIJ˜µ³	æ
¾N7"¼(Zfí6Ñq# ®ƒ
Gz�ƒNi¤@pÚøÿÏÒ
bikyÁâfty{ÂöøŠ46  $Z$=íã‰¶¸
Ã1A³ÉÜ|C7Ë–  Ë M…q…*Yò]Ž¦ÑÖ	â	â`òÄrƒzí"‡É¹B8 .ÚûÊv<`‡Èä-©	
mi…“î)½!=—<²ô{  ±Âæâ0	’
Ú\ßä8btpÅ;L Œ­U©Ñúž§æïb®	¨WeËú"qËŒäØ|)  ë
ôX¡ï`{�–Å{Çó$	ePä63¡Ê©òÀ…Ìún+Iƒ
)0‰- -dî/BzPh|›é#ƒ#VotÔ'	„
ó
wXš<|
/7@Áí
…2ð%ùO Ê  ß T¢
U‡t¦ËÞ~¬� ž«V¯¬Eûœ A K a Ó ™¦€b˜×²ú�.4I h Ñ~Õò‰
º
þ
‹éRnmîšr n‹3ÿÅ
?‚ »1[ Ž O…ãŠº¼	É	è	C6áþ®µäK¶»ÉÓâ£}¤ H N Á W¦ü€Ô\RÔbÅÛ•þéèc „ Ö 3©W†	GR(Ñ±%d IÍ q É +bu-8AÏÞíü[nŸÐ±	œä`5czÜOÙ9ó ' o jlÏá¸ÅÒCIØÚ : E ÿ =–£Ú³çQ“S/\‚-žÈ<ºæ`cxŽ˜# &eu¡ŠØö‹©
þÇ½G>�Ôö38†€žÏ)KÁ˜šÓÌo%  ) V ‰ 4’\3?Àivö+
Û
jiÏŸ˜¤0]MR\ € kŒ¿Ñ&¿ï÷7í
Ûˆª.yŠ` ‚ø*p–æ¨ñóIO ¦”iy™ºÇåž	
x•EQŒ“Ùô^yf³# …¸�±t�×õ�d	Ø	!
Ã 1��¬l\>½ê‹çK¿Œ: / 5 < · ì ?ØùC:QI‚½ún 0’ôR»De‘p! 
‚É	M_h~†?ˆµÙã¨á	áÂ„í¼Ã ‚ì!‰±z3# 
 å‹ó" _•Ä"UsÓò
­Ù56 ÊÞã7ñ!1ï$*HN{  ` ˜Ô�Ta†s±ùl™›Œ G „Š‰¥VÄ
Ó5FQ[Ú�µºÈýè|Z  9 D atdÙ‰Î×ÝìûÏ[_ÇÑ7…�J—™ÒËØbnw U  ˆ ¥x6hÚ
iÎÚ‹Ø/ó]xð²ò" 	 ·×	9P�ŠL^sô>‡c	à	¼œ¬ƒ6¼ QŠJ� ƒˆg~ÎS`hÒEPZ^ÍÆ´Ç˜Ñ{ñmšY2  ¶O€‡¶[\]fª=
²³UVWXY™š›«Í�‚T|úûX‰³Æ
ðXY( æ }æ%·C¥«7AG½5
>
3´'ÎðUM}õ	tôüZŸ¸Y!öZ½!  ¸,BþB	H	ó	T
*µ(Ïñ/‚ôãNr´n§×åÝ"¡™Æ d ¥Ì
µÐÜé¦ä	’]ö
	¦&UYç÷[) ‡DsÅÑáDn¦S¬ßð6
Ï
_>~Vóý`± ¹�Zë+–. x Í ç ~ç&Ã¸ÈÜ73™8Hž¾		9	9
?
4Zä5„bÕÃS~u“õHNý[|dT²¾ œ«‰«ÿX	ô	U
t
G)Ð0K«sûgo¨ØÞ¢šÞ ƒµ#
sçƒ›¿aOJ#ÇÖø 0Ý	í¿Çykmâ+#@6DG®Õ  Ÿ¹-CgÊC	I	h
"+¢¶ò–ãõÖäîø µR^æMA Íb‰êæ/O	oµýkÃÛƒ‚©/Ó
lœZ´èqÿ! Q ½ ò EÃÿZÑà*	;÷­õÚ‡þ-‹*¼EšÍnX©\! ] e (œmwÝ–™�§då	+M@^¦*:ek�'VÒö(†‰L Ý¦m—¶Kœ“ð0Eî÷�ÕéV‡Ã|§Š>Îø' xØÜ"@Etx§0àñ.	
�
`u{ÕSÌW?ÃÊdëc,'‡ �hgsŸUä1? 
AôaP[Ñä& 7ˆ£ÆÒÿAJqÕTÌ7	@	7
Ðßºþ	²5F.�òV¤îL—°åîR î âEo!­Ê]	  «ó?$.¤u¡ºÑCì§}æý y :Ý9Ÿ:	[,6Ac•rˆI}™ øÕ_©þ³" è èð'¡©VÄú¹8Œ¿
	Éå…ÉIT—#”ö þê5*’ÛßÁ$ ý'ÌÉ>G0Úøc¯²¾4ºí	:
Ö&9Ä”vOwN°Èž¦U# Î ¬4šIOú	_	n	ø	@
«
5O‚‹ÊÓ
¸Ý\i£:e€¿èî,!  X àÇô1;¬æ|	Ò	î	V
u
Î
H»Ïù�žü)©_Tó^›ß �[¬^	Y	‘	¡	Ñ¬yt¦�ß°<†Ú ‹ L³ÔQ^èAMõ	¯{—·Ñ3h}’šÙ"<‚a–£" Ä[Š 		*	2	¶	z
½
Ë
/l*1Le¹^atl°‰pv¦úŽ=S —„¶T	
k¯?œ H¡yu~¹tDP W�Òí:³#9þu Ã  ù
]À,àPOk«Èë ª Â$tŽÌè„b,4K$@F@7×ùu ËXîó¡ä
^À ™Èn°A7Ö Ç ”1Å�–¦`:â    - } �ßáÞ	3
(ÁÍîÓëŽzálïøXã$H¯”ÿ » ð Cý5¸ëø>	r
9H,>EVÔ  + { ä	<	¬	ì	1
±
É
Ý
U·ä!œ%'í2|iµN GÎ	i
”
À
ß
óoÜ—åê´4½Ä#·+   Þe.U²kxDx®	ê
kQ~ÀÚŠæñCKS_d'rˆµÆçÇ	i‡A¶B2 — £ ± Ù 6X<ºñhkËD	J	j	r	-
³
ù
#,£·".8Cq[wæö×ïù7Y\†¶	›N×	k îç‚û	b
}
†’½ÎÚâqªÄÜù„ª¶ÛCTg0r # r½Óü`�ÂNŽP	Ä	Œ
–Þd‡D¤0pŠ+6”¿µu h‰¼«!Îü'°p2øÔ·ÕmðkáÆÃ "( X±´cŠë0	k
–
á
ö
�¶×þl´Þéç™ÍƒÐWZ(�¨¬[Þéü  0ê×*[¹áP
<Ûÿˆ‹ÿ0+ì$Fo$ªej  )I¸Á“^9zçJ è°Ýñú%ŒÈÓý›Ž%¨T R ¾ Ü ó FÄ Òt'›	›	¹	(
®öHYæ.�½Î÷s Y]x § 6»ùÓ+ëo
ñø¹A;¿š"7Íh Þb m©ÀxŽŸ:WŽÁ¥íHõN'A§;fÀ�{…Ó÷€~ f m ‚ Ñ )n¾æ	‡
g‰l�¬ ,æpMŒ 3 ^ µ ê _÷A}¯ñ|¨ 
Â
<Ë€Ø(W)Šk»# Ž�ÁSk•Þ—šeM ©ñ,K”™Ù_ìCì+(aÝ4ü‡ì ÞY�	Ð	¯
&”ËÊ¤FÄüD}…?: §¯(«·L?ïøŽ–˜Ö¢n¹ £©Æn˜-�ü•
ï
ôñêWˆQ^¬ÏáÒ ò½­&)×
D
I
o1ˆVº¨
‹ÚùÍ+ š [yÌÝÿ#E˜"Zk1MÀ}Úu	 
™
ë:ÅÍXoŒ«»ôaðS`d ž ôÊè—´‰	§AM|ÖTžóS£»YÎeì5-áÐD$ ÙúL<Fpuyì£Çþ,�Î
·
ah’á(ñe@qxy–Èõó¸/  íAgš¬èT¨WznzÆáò#	&	/	ƒ
‘
vO§;d{2?ìas„ÄËpÊã	(/ˆ @ }¥ñ¡
ý
¥QU®«ú V2…	B'QÄÐŸÒ! <¢i,t Îà7@õZm’R°	ý.�,4¼
€õbH(åò �‘)2h•¾åö˜
õì
w”‡£©\L-_  „�Èg…ÖŸ´rñ
�àÁØ4m»5«ÿÂ[/‘óæM2o ‡ s‰ÓØœÖÜúUÐ6ŠIü\ï±‹- å |$8‰BKre}†¤Í6@F¼b	<

2Rg»Ñ˜ª€SÌóž·PW²Ð	zïõW%  ¤ÇË 	¥Û2˜ïý		8	A	G	8
Âòü
_q³GM¦Ü¥T ˜æS ›´"ˆÉg
!ræªâÆQ]flCÔ# Ül•c	N	ö¬ô/ý¥)ŒÔèU†Š)»ÂÒDk{‰Ñ…¨K~þ! w×!?rã0@Ip/Ë-	6	
Ÿ
@ÞtzROEtÉñíK¦Qü% ï9«F/b®±3N^	m	ŠÒ+@·%8Ü–hv¢é9‘Ú^�¨ç+ ó0L:)	 	.ºdz–s¶k€ˆ¥Ž!;ù�¯ò`R –
\j�>ì9ß+?~¸ªCÂêt Þœà 8]˜Gá=ÿ3 z – ¢ ° W;ðdTjw	;	i	q	«	0
é
!-7BpZP}¿ÙX[‰ðJì‡š{ÖÃhµ"´, " gªW¼û _&¯Á�	ú	a
õ
…Ž¼ÍÖ1†èø˜÷ÏÚSÔj“§«àÂû! ¦ Û /é(·º'
O
n
yæŠ/:¾$!ë6ög#Ý& l ´ Ð é ¨ö@¿|Rj~”ž9{½À
†
Ÿ;GÊJ&Bÿ+`Ü'„û ñ¢¼®Å%(XÖ
C
H
®
%ÊÉ‡U¹•¡P]„mÑÌ( ™ ZþDóëS!jÉç¿+mÍÙ"	t	‚
¶
¦‘�':z1>wº`xƒ•4ÉÏ. ;€(1”Í6Qü
ü-&¤Ãžªñ' rÊf›¤1Ûùd…³5q»îü		F	a	;
	Qº×3ñû^�¥ÛO±ŸV k?H.°M	5	M	l	qsyÅ•NPkÙ§ • ¯ VS›ßv	p	ª	/
7 ¹y—Þï>:<QÁé+ k ¥ ³ Ï fõ?­�%¼ù	

B
G
N
`
­
x„�ÌÕ0:F~%9¸½iƒfƒÐÜ : 5iLPû	L	`	�
µ
û
P¥¹û%œ_j‚¤ð-+ ­ ® 89ô>JKo	

A
F
K
L
M
¬
6wƒŒËÔ$E¼]^;h�‚Àï  .~  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           *                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  	                                                      	                                                                                                                                                                                                           )                                                                                                                                                                   	                                    
            6      
      
                                                                                 	                        3   #         "                   ~   `                     Y                                                                                                                                                                      *                                                                                                                                                                                                                                                                                                  	                    	                                                                         )                                                         	            
    6  
  
                           	        3 #   "       ~ `       Y   vi  wƒ  w—  wÉ  |  �  ‡W¿‹%”k ¼¿H!Sàv»	"	t	ù	
N
O
n
µ
ûB]}˜!Ïá‡žñ7º•ÝÅ}
Z"éX�@Ì” U®ÎlååÅ,|
Ÿç ” .U²ÊòlpÌ(	4	¯	|
•
¿
Á
ë
$Ÿçiog»Ò]cØü+8¹å9|î*®ªÄœÀ³ñ'€"7�˜ñ"@7ñ"7"˜"Ó©}'4Ó:…ÍÚö	rÆ½^
ØÁÊÜòè‚³ÔíóŠDÓ¥vy»~
ÓœX	ÐÕ©I¢ãiù	`
9Ñ¡¡¹ î Aû¶éÒBIÕ÷’
Úy=í’’Nmu˜¿Ù‰zƒ’ÆMhÀµÂ;MòVó£ÎË æ¹ î Aû¶éu5„TÒÜ‰* ¿K? ¤t˜	ùã¡ù‚×ùù×´¹F ZÙç¤|ðù’<™ù×Æžt˜…d
œ
ßFÆlÔuoþ?	¤ì¨
Fs�‡×9f%0i·
§È‡-Ü÷
ÿ
uA³�
ã’žNe¦	ö	#
XmˆÐu˜¿Ýf�b°«–‘/ý)D¨«ï
’”¤¨þž ijX À	ù	ú	`
a
„ÌGj¤¹&º_KŸ	•� _Xrñ (K(	-µj‡ŒÓ‘F®�Õ˜
nï¨h«@¨žÀG&  t˜	ù…’d
œ
<™ã¡ßù‚×$í�¿B¨žÀG¤&6	EQêÓ¥” U|RYðluÈ!	(	ÿ	.
f
|
ô
-‘¤Ùì
ÄŸáç04j‡îxÎó#ªO¨žX À	G&V¤ì¿’žZ	�
Ò!¡@K¡­­¾ã +�e ”ìÅ˜êá¹	ƒˆ´Ç{\w:,6A™Õt˜ó£«ÎË –‘æ±Šë�×W(Wz#	Ëµ¦î). IÕ÷Œ. Y#%¼ù‘ÈÙBIùá×Õ÷ úàƒŒ!0…Ú‡ÃÌWƒÝþ Eû¨.�òE�’Þèx* ¹}5ªW	Â9(	-j‡XdTw		–
Þµi=·ˆ´§–
ÞIÕ÷‰´ý)/D¨å^¿‹)ArÚô	g¢ö   piŠ½$ízu	×
2‘×ÕžZ	Òê!¡@¡­ÛŸp’öL®~¿ì™ ZþD!j¿Ùt	ú	a
…¼ÍøºÚS`íÉ|ï—	
Þ ì³fVyyÅ%	j
•
à
N³ÝcæÌ`rVY'oÝ “ T%‘ø‘¾Ý		f	ö	$
^

œzfµÆ¤ó0:¹ºy€:òQ¬G$X
Š0§Šø%‘ø‘¾	ö	zÆ¤³j
•
à
³ÝæÌVY'Ý ìfVyyÅ%	Nc`roRj”ŸJB`ÜûÒ'�®Zµ	k¥\ Ãìï³fVyiyÅ	%	1	h	j
y
•
¼
Ê
à
oNY³¸Ý]`cO¯ØæZÌ`ruë†VY'oÂÝ<!™ ZóþD0!j¿:Ùt	ú	a
…¼Í¹ºyø€ºÚS`:òQL¨ð˜Øëë3ë¯VU-—Lê9R_gª &¯1÷ÔjàÂ!zä­ÆŽM(ÝüN	Òkþô|-Dá x <çÿ‚ù÷	�É	Š K]ùK@oûý®ðdÐF™à¶ïòôÓ2œN	|Òk-þD‹«!'mkÆn˜ü•ñêWQ^áE	5„%g=	U• ¯ VSv	p	ª	/
 ïÆåí	Í
ø�(ÚSlH¨ÝU	ÆÜ[áQv[¦27ú„Âr
Ìè4H$>EÔ×œ«O	X	[{ÐÕS«s/}Þdë©´,Ê¤1îü		F	ñû^¥ÛŸ�“	£	[
ü±²~ Õ 2HHwJÙ
å
ï!Ù$c×ò=wÌÏêoÓ¥I�£Æÿ7	@	7
	²F¤—åRSH¨U	Æ2ÚÜ[7úHHJå
ï!=lÝ[áQv¦„Ãïi	1	h	y
¼
Ê
oY¸]`O¯ØZuë†Â<!«!n˜'ü•ñêWQ^mkÆáèB¢dÀd 
Ü¦ä	]&U�	;ÙÝŸþ + { ä	<	¬	ì	1
±
É
Ý
U·ä!œ%'í2|iµNz – ¢ ° W;ðdTjw	;	i	q	«	0
é
!-7BpZP}¿ÙX[‰ðJì‡š{ÖÃhµ"´²ÓPÃÆçZ]å		1	í	y
¼
Ê
Í
¸ø]`x¯�(2u|‘�•<… 3j‹¾[“÷%>î¹Æä§u�™:Öó1²—
>?µ¿ß©ÎSYoÎ„fîïø\›] Ýã­	“
²
¿
È
Þ
ø
 nv¶Ûåé›å&Bcq´Æ3¼j¶M@ }¥ñ¡
ý
¥QU®«úŸ[	Ž
ÓØë"pÁÊ’¢öALT¢®l~¬®¿ãÜäì  “ TQ¢Ý	 	3	g	%
^

�+hn¢ÇNiÍØêœf¶Áó0L:)	 	.ºdz–s¶k€ˆ¥Ž!;ù�¯ò`Rm©ÀxŽŸ:WŽÁ¥íHõN'A§;fÀ�{…Ó÷€~  i “ œ Tu{�™ÊÕµ:]ÖQdƒ¢Ù“ó¢Ý1†‹²Ä	 	+	3	g	ƒ	þ	%
^
e
l

—
�
0>�+?ˆÐKhn–¢¨µ¿*2MfºÃÇßQbu´àêûNim’©¹oŠÎSYo£¸Îq„ÍØêfîó[œ§ÒïZf�©­¶øR\›Á]m' f m o q ‚ É Ñ )+bmu©jlÀ-nxŽÏáŸ:W8A¾ÏÞíü[nŽŸ¸ÐÁ±	æ	‡
œ¥äíH`Åõ5Ng'A‰c§Ò;Cfl�¬À Iz�ØÚÜ,O{…ÓÙæ÷9pM€Œó~º Æ ï B“ü4Äí·ê÷q
'•ÀÌê¥~“ÓŒ­U©Ñúž§æïb®	¨WeËú"qËŒäØ|S ¶Ã <œNY]¯÷Só€‘Ü¸êéWyk?H.°M	5	M	l	qsyÅ•NPkÙ§dö ;cxÓ�	fl‘” è(°/2vW=G „Š‰¥VÄ
Ó5FQ[Ú�µºÈýè|Zº Æ ï Bq“üeu�™4j“ò÷:Öšï<ÄÈæó-í*1²·Øê÷	q
—
'>p•ÀÌ?¾µ¿�ßê2y¥©=iÎMSYoÎ„3f”ÌßîwÚï~©ø\›“ÎÓ>]ƒµ#
sçƒ›¿aOJ#ÇÖø   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="Zdhhc15-m" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1812" maxFusedRunOn="1812"><Segment range="706-1716" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MRRGWKMALSGGLRCCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFAWTYWKSIFTLPQQPNQKFHLSYTDKERYKNEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNGFNLGFIKNIQQVFGDNKKFWLIPIGSSPGDGHSFPMRSMNESQNPLLANEEPWEDNEDDSRDYPEGSSSLAVESET"/></Q></Feature><Feature recentID="1" name="RBS" type="RBS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1348-1359" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;strong bacterial ribosome binding site (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10659856&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10659856&quot;&gt;Elowitz and Leibler, 2000&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6667" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5876-6667" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6668-6736" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="3" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3575-4369" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1833-2421" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5117-5705" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2737-3165" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3179-3508" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3359-3494" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4545-4666" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6737-6841" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2487-2535" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4763-4769" color="#ffffff" type="standard"/><Segment range="4770-4787" color="#ffffff" type="standard"/><Segment name="-35" range="4788-4793" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4808-4829" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4715-4731" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4739-4755" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1812" maxFusedRunOn="1812" detectionMode="exactProteinMatch"><Segment range="1723-1749" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="19" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1812" maxFusedRunOn="1812" detectionMode="exactProteinMatch"><Segment range="1753-1779" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="20" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1812" maxFusedRunOn="1812" detectionMode="exactProteinMatch"><Segment range="1783-1809" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¦<Notes>
<UUID>eb9de375-7819-4335-a89c-684442e580b2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Zdhhc15(mouse)-3Ã—HA-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="0:0:39">2025.9.21</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             	<StrandColors><TopStrand><ColorRange range="699..704" colors="green"/><ColorRange range="1716..1721" colors="green"/></TopStrand><BottomStrand><ColorRange range="699..704" colors="green"/><ColorRange range="1716..1721" colors="green"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
